Exposure to welding fumes may result in disorders of the pulmonary, cardiovascular, and reproductive systems. Welders are also at a greater risk of developing symptoms similar to those seen in individuals with idiopathic Parkinson’s disease.
In welders, there are studies that suggest that alterations in circulating prolactin concentrations may be indicative of injury to the dopamine (DA) neurons in the substantia nigra. The goal of these studies was to use an established model of welding particulate exposure to mimic the effects of welding fume inhalation on reproductive functions. Because previous investigators suggested that changes in circulating prolactin may be an early marker of DA neuron injury, movement disorders, and reproductive dysfunction, prolactin, hypothalamic tyrosine hydroxylase (TH) levels (a marker of DA synthesis), and other measures of hypothalamic-pituitary-gonadal function were measured after repetitive instillation of welding fume particulates generated by flux core arc-hard surfacing, manual metal arc-hard surfacing, or gas metal arc-mild steel welding or manganese chloride.
Exposure to welding fume particulate resulted in the accumulation of various metals in the pituitary and testes of rats, along with changes in hypothalamic TH and serum prolactin levels. Exposure to particulates with high concentrations of soluble manganese (Mn) appeared to exert the greatest influence on TH activity levels and serum prolactin concentrations. Thus, circulating prolactin levels may serve as a biomarker for welding fume/Mn-induced neurotoxicity. Other reproductive measures were collected, and these data were consistent with epidemiological findings that prolactin and testosterone may serve as biomarkers of welding particulate induced DA neuron and reproductive dysfunction.
Find the full paper here.
Don't miss our latest HSE content, delivered to your inbox twice monthly. Sign up for the HSE Now newsletter. If you are not logged in, you will receive a confirmation email that you will need to click on to confirm you want to receive the newsletter.
5 - 7 Oct 2020
- Denver, Colorado, USA
Join thousands of E&P professionals for technical learning, networking and collaboration
7 - 10 Dec 2020
- Amsterdam, The Netherlands
Delivery for the Energy Challenge: Today and Tomorrow
17 - 19 Aug 2020
- Kuala Lumpur, Malaysia
Where Energy Professionals Exchange Ideas
29 Aug - 2 Sep 2020
- Tulsa, Oklahoma, USA
Get back to basics in oil recovery
2 - 3 Sep 2020
- Beirut, Lebanon
Join peers and colleagues at this premier event
9 Sep 2020
- Calgary, Alberta, Canada
Enter into the World of Tomorrow for Canadian heavy oil
14 Sep 2020
- Bergen, Norway
The SPE Norway Subsurface Conference brings together the E&P industry to expand industry technical knowledge, connect with innovators and leaders and address technical challenges facing upstream oil and gas professionals.
HSE Now is a source for news and technical information affecting the health, safety, security, environment, and social responsibility discipline of the upstream oil and gas industry.
©2003-2020 Society of Petroleum Engineers, All Rights Reserved.